Contrave contains a mixture of bupropion and naltrexone. Bupropion is an antidepressant medicine that helps to decrease appetite. Naltrexone is usually given to control the effects of narcotics or alcohol in people with addiction problems. Naltrexone might also curb hunger and food cravings. Contrave is an anorexiant amd which is used to help and manage weight in obese or overweight adults with weight-related medical problems. This drug is usually used together with diet and exercise. Contrave will not treat any weight-related medical condition, such as high blood pressure, diabetes, or high cholesterol. Contrave is not approved to treat depression or any other psychiatric conditions, or to help you quit smoking.